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Adipose tissue, now considered as an endocrine organ secretes various proteins (adipokines) that are involved in derangement and progression of metabolic functions by local and systemic actions.[11] Adiponectin, a fat protein from adipose tissue has shown to possess cardioprotective effects. Its anti-inflammatory and anti-atherogenic properties have been confirmed in various experimental models. Low level of adiponectin has been found in patients with diabetes, dyslipidemia and obesity. Therefore, hypoadiponectinemia has been proposed as an interesting hypothesis to explain the pathophysiology of metabolic syndrome.[12] Excess secretion of free fatty acids from adipose tissue is also associated with insulin resistance by reducing glucose transport into the muscles. An approach toward reduction of free fatty acids in plasma appears to be a potential target in the treatment of cardiometabolic syndrome.
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